Injections
Cefrishot-TZ Injection
Ceftriaxone 1000 mg and tazobactam 125 mg injection
Cefrishot-TZ is a registered product of Ramnova Healthcare Private Limited.
Cefrishot-TZ Injection composition
1.125 g presentation
| Ingredient | Strength |
|---|---|
| Ceftriaxone | 1000 mg |
| Tazobactam | 125 mg |
About Cefrishot-TZ Injection
CEFRISHOT-TZ is an injectable antibiotic that combines ceftriaxone 1000 mg, a third-generation cephalosporin, with tazobactam 125 mg, which protects ceftriaxone from bacterial enzymes. It is supplied as a 1.125 g vial and used to treat serious bacterial infections, including meningitis, blood infections, and infections of the chest, abdomen, urinary tract, bones and joints.
It is given by a doctor or nurse as an injection into a muscle or vein, usually once a day. The most common side effects are diarrhoea and rash. Tell your doctor straight away if you have ever had an allergic reaction to penicillin or any other antibiotic.
Therapy category: Antibacterial medicine.
Uses of Cefrishot-TZ Injection
- Meningitis and septicaemia
- Respiratory tract infections
- Intra-abdominal infections
- Bone and joint infections
- Urinary tract infections
- Pelvic inflammatory disease
Benefits of Cefrishot-TZ Injection
Meningitis and septicaemia
Ceftriaxone reaches the brain and spinal fluid well, so it is widely used for bacterial meningitis and serious blood infections. Prompt treatment in hospital is essential to clear the infection and prevent complications.
Chest and abdominal infections
It is active against many bacteria that cause pneumonia and infections inside the abdomen. Tazobactam blocks the enzymes some bacteria use to resist ceftriaxone, helping it work against a wider range of bacteria.
Urinary, bone and joint infections
It treats complicated urinary tract and kidney infections, as well as infections of bones and joints, which may need several days or weeks of treatment as decided by your doctor.
Pelvic inflammatory disease
Infection of the womb, fallopian tubes or ovaries can cause pain and affect fertility if untreated. Ceftriaxone is commonly used, often together with other antibiotics, to treat it.
Side effects of Cefrishot-TZ Injection
Most side effects are mild and settle as your body adjusts. Tell your doctor if they continue or worry you.
- Diarrhoea or loose stools
- Rash or itching
- Pain, swelling or hardness at the injection site
- Nausea or vomiting
- Changes in blood counts or liver test results
How to take Cefrishot-TZ Injection
This medicine is given only by a doctor or nurse, as an injection into a muscle or vein, or as a slow drip into a vein. Your doctor will decide the dose and how long treatment lasts. It must not be mixed with calcium-containing fluids such as Ringer's solution.
How Cefrishot-TZ Injection works
Ceftriaxone is a cephalosporin antibiotic that stops bacteria from building their cell walls, so they burst and die. Some bacteria make enzymes called beta-lactamases that can break down antibiotics like ceftriaxone. Tazobactam blocks these enzymes, helping ceftriaxone keep working.
Safety advice for Cefrishot-TZ Injection
- Safe
Alcohol
No harmful interaction is known. Avoiding alcohol can help your recovery from infection.
- Consult your doctor
Pregnancy
Used during pregnancy only if your doctor considers that the benefit outweighs the risk.
- Consult your doctor
Breastfeeding
Small amounts pass into breast milk and may cause diarrhoea or thrush in the baby. Ask your doctor.
- Use with caution
Driving
Can cause dizziness. Do not drive if you feel dizzy or unwell.
- Use with caution
Kidney
Tell your doctor if you have kidney disease, especially if you also have liver problems, as the dose may need adjusting.
- Use with caution
Liver
Tell your doctor if you have liver disease, especially if you also have kidney problems, as the dose may need adjusting.
Quick tips
- Before the first dose, tell your doctor or nurse about any past allergy to penicillins, cephalosporins or other antibiotics.
- Tell staff immediately if you develop an itchy rash, swelling of the face or throat, or difficulty breathing.
- Complete the full course your doctor prescribes, even if you start to feel better.
- Report diarrhoea that is severe, watery or bloody, even weeks after treatment ends.
- Report pain in the upper right side of the abdomen, yellowing of the skin, or unusual tiredness or paleness.
- Rest, eat well and drink plenty of fluids to support your recovery.
Warnings and interactions
Safety details must be checked against the current pack insert and advice from a qualified healthcare professional.
Warnings
- Serious, sometimes life-threatening allergic reactions, including severe skin reactions, can occur. Tell your doctor about any previous antibiotic allergy.
- It can cause a serious bowel infection (Clostridioides difficile colitis). Report severe or persistent diarrhoea.
- It can cause sludge to form in the gallbladder, especially at higher doses, which may cause abdominal pain. This usually clears after treatment stops.
- Rarely, it can cause anaemia due to the breakdown of red blood cells (haemolytic anaemia).
- In newborn babies it must never be given with calcium-containing fluids, as deposits can form in the lungs and kidneys.
Contraindications
- Allergy to ceftriaxone, tazobactam or any other cephalosporin
- A previous severe allergic reaction to any other beta-lactam antibiotic, such as a penicillin or carbapenem
- Premature babies, and newborn babies with jaundice
- Newborn babies who need calcium-containing fluids into a vein
- When lidocaine is used for injection into a muscle: allergy to lidocaine or certain heart rhythm problems
Important interactions
- It must not be mixed with, or given at the same time as, calcium-containing fluids.
- It can increase the effect of warfarin and similar blood thinners, so your INR may need checking.
- Kidney function should be monitored if it is used together with aminoglycoside antibiotics.
- Chloramphenicol may reduce its effect.
Frequently asked questions about Cefrishot-TZ Injection
- Cefrishot-TZ Injection is used for: meningitis and septicaemia; respiratory tract infections; intra-abdominal infections; bone and joint infections; urinary tract infections; and pelvic inflammatory disease.
- Common side effects of Cefrishot-TZ Injection include: diarrhoea or loose stools; rash or itching; pain, swelling or hardness at the injection site; nausea or vomiting; and changes in blood counts or liver test results. Tell your doctor if they continue or worry you.
- This medicine is given only by a doctor or nurse, as an injection into a muscle or vein, or as a slow drip into a vein. Your doctor will decide the dose and how long treatment lasts. It must not be mixed with calcium-containing fluids such as Ringer's solution.
- Do not take Cefrishot-TZ Injection in the following cases: allergy to ceftriaxone, tazobactam or any other cephalosporin; a previous severe allergic reaction to any other beta-lactam antibiotic, such as a penicillin or carbapenem; premature babies, and newborn babies with jaundice; newborn babies who need calcium-containing fluids into a vein; and when lidocaine is used for injection into a muscle: allergy to lidocaine or certain heart rhythm problems.
- No harmful interaction is known. Avoiding alcohol can help your recovery from infection.
- Used during pregnancy only if your doctor considers that the benefit outweighs the risk.
- Can cause dizziness. Do not drive if you feel dizzy or unwell.
- Cefrishot-TZ is a registered product of Ramnova Healthcare Private Limited, Silvassa, India, and is marketed by Ramnova Healthcare.
- Cefrishot-TZ Injection contains ceftriaxone 1000 mg and tazobactam 125 mg in each vial.
What is Cefrishot-TZ Injection used for?
What are the side effects of Cefrishot-TZ Injection?
How should I take Cefrishot-TZ Injection?
Who should not take Cefrishot-TZ Injection?
Can I drink alcohol with Cefrishot-TZ Injection?
Is Cefrishot-TZ Injection safe in pregnancy?
Can I drive after taking Cefrishot-TZ Injection?
Who markets Cefrishot-TZ Injection?
What is the composition of Cefrishot-TZ Injection?
More information
Marketed by Ramnova Healthcare Private Limited, Silvassa, India.
For dosage, pack sizes or prescribing information, refer to the current pack insert or contact Ramnova Healthcare. Catalogue information updated 2026-10-01.
- electronic medicines compendium (emc): Ceftriaxone 1 g powder for solution for injection or infusion: Summary of Product Characteristics (United Kingdom, accessed 2026-10-01)
- electronic medicines compendium (emc): Piperacillin/tazobactam 4 g/0.5 g powder for solution for infusion: Summary of Product Characteristics (United Kingdom, accessed 2026-10-01)
