Injections
Piproshot 4.5g Injection
Piperacillin and tazobactam injection
Piproshot 4.5g is a registered product of Ramnova Healthcare Private Limited.
Piproshot 4.5g Injection composition
4.5 g product presentation
| Ingredient | Strength |
|---|---|
| Piperacillin | 4 g |
| Tazobactam | 500 mg |
About Piproshot 4.5g Injection
PIPROSHOT 4.5 g is an injectable antibiotic that combines piperacillin 4 g, a broad-spectrum penicillin, with tazobactam 500 mg, which protects piperacillin from bacterial enzymes. It is used in hospital to treat serious bacterial infections, including severe pneumonia, complicated urinary tract and abdominal infections, skin and soft tissue infections, and fever in patients with very low white blood cell counts.
It is given by a doctor or nurse as a slow infusion into a vein, usually every 6 to 8 hours. The most common side effect is diarrhoea. Tell your doctor straight away if you have ever had an allergic reaction to penicillin or any other antibiotic.
Therapy category: Antibacterial medicine.
Uses of Piproshot 4.5g Injection
- Severe pneumonia, including hospital-acquired and ventilator-associated pneumonia
- Complicated urinary tract infections, including kidney infection (pyelonephritis)
- Complicated abdominal infections
- Complicated skin and soft tissue infections, including diabetic foot infections
- Bloodstream infections linked to any of the above
- Fever in patients with very low white blood cell counts (neutropenic fever) due to suspected bacterial infection
Benefits of Piproshot 4.5g Injection
Severe pneumonia
Piperacillin with tazobactam is active against many bacteria that cause hospital-acquired and ventilator-associated pneumonia, including Pseudomonas. Treating the infection promptly helps clear the lungs, ease breathing and reduce the risk of complications.
Complicated urinary tract and abdominal infections
Infections of the kidneys, urinary tract or abdomen are often caused by a mix of bacteria. Its broad range of activity covers many of these organisms, helping to control the infection and stop it spreading to the bloodstream.
Skin, soft tissue and diabetic foot infections
Deep skin and diabetic foot infections can involve several types of bacteria. This combination helps stop the infection spreading and supports healing alongside proper wound care.
Neutropenic fever
People with very low white blood cell counts, for example during chemotherapy, can develop life-threatening infections. Starting a broad-spectrum antibiotic such as this one quickly is an important part of their care.
Side effects of Piproshot 4.5g Injection
Most side effects are mild and settle as your body adjusts. Tell your doctor if they continue or worry you.
- Diarrhoea (the most common side effect)
- Nausea or vomiting
- Rash or itching
- Pain, swelling or redness where the infusion is given
- Headache or difficulty sleeping
How to take Piproshot 4.5g Injection
This medicine is given only by a doctor or nurse in a hospital or clinic. It is dissolved and given as an infusion into a vein over about 30 minutes. Your doctor will decide the dose and how long treatment lasts, based on the infection and how well your kidneys work.
How Piproshot 4.5g Injection works
Piperacillin is a penicillin antibiotic that stops bacteria from building their cell walls, so they burst and die. Many bacteria make enzymes called beta-lactamases that destroy penicillins. Tazobactam blocks these enzymes, so piperacillin can work against a wider range of bacteria.
Safety advice for Piproshot 4.5g Injection
- Safe
Alcohol
No harmful interaction is known. Avoiding alcohol can help your recovery from infection.
- Consult your doctor
Pregnancy
Used during pregnancy only when your doctor considers it clearly needed.
- Consult your doctor
Breastfeeding
Small amounts pass into breast milk. Your doctor will weigh the benefits; watch your baby for diarrhoea or rash.
- Consult your doctor
Driving
Its effect on driving has not been studied. Do not drive if you feel dizzy or unwell.
- Use with caution
Kidney
The dose is reduced in kidney disease, and your kidney function will be monitored, especially if you are seriously ill.
- Safe if prescribed
Liver
No dose change is usually needed, but tell your doctor about any liver problem.
Quick tips
- Before the first dose, tell your doctor or nurse about any past allergy to penicillins, cephalosporins or other antibiotics.
- Tell staff immediately if you develop an itchy rash, swelling of the face or throat, or difficulty breathing during or after the infusion.
- Complete the full course your doctor prescribes, even if you start to feel better.
- Report diarrhoea that is severe, watery or bloody, or that continues, even weeks after treatment ends.
- Report any unusual bleeding or bruising.
Warnings and interactions
Safety details must be checked against the current pack insert and advice from a qualified healthcare professional.
Warnings
- Serious, sometimes life-threatening allergic reactions, including severe skin reactions, can occur. Tell your doctor about any previous antibiotic allergy.
- It can cause a serious bowel infection (Clostridioides difficile colitis). Report severe or persistent diarrhoea.
- It may cause bleeding problems and low potassium levels, so your doctor may check your blood during treatment.
- It contains a significant amount of sodium. Tell your doctor if you are on a low-salt diet or have heart failure.
- In seriously ill patients it may slow kidney recovery, particularly with vancomycin. High doses can rarely cause fits, especially in people with kidney problems.
Contraindications
- Allergy to piperacillin, tazobactam or any other penicillin
- A previous severe allergic reaction to any beta-lactam antibiotic, such as a cephalosporin or carbapenem
Important interactions
- Probenecid increases the levels of piperacillin and tazobactam in the blood.
- People taking blood thinners, including heparin and warfarin, may need more frequent blood clotting tests.
- Piperacillin can raise methotrexate levels, which may need monitoring.
- It can prolong the effect of muscle relaxants such as vecuronium used during surgery.
- Using it with vancomycin increases the risk of kidney injury. Aminoglycoside antibiotics must be given separately, not mixed in the same infusion.
Frequently asked questions about Piproshot 4.5g Injection
- Piproshot 4.5g Injection is used for: severe pneumonia, including hospital-acquired and ventilator-associated pneumonia; complicated urinary tract infections, including kidney infection (pyelonephritis); complicated abdominal infections; complicated skin and soft tissue infections, including diabetic foot infections; bloodstream infections linked to any of the above; and fever in patients with very low white blood cell counts (neutropenic fever) due to suspected bacterial infection.
- Common side effects of Piproshot 4.5g Injection include: diarrhoea (the most common side effect); nausea or vomiting; rash or itching; pain, swelling or redness where the infusion is given; and headache or difficulty sleeping. Tell your doctor if they continue or worry you.
- This medicine is given only by a doctor or nurse in a hospital or clinic. It is dissolved and given as an infusion into a vein over about 30 minutes. Your doctor will decide the dose and how long treatment lasts, based on the infection and how well your kidneys work.
- Do not take Piproshot 4.5g Injection in the following cases: allergy to piperacillin, tazobactam or any other penicillin; and a previous severe allergic reaction to any beta-lactam antibiotic, such as a cephalosporin or carbapenem.
- No harmful interaction is known. Avoiding alcohol can help your recovery from infection.
- Used during pregnancy only when your doctor considers it clearly needed.
- Its effect on driving has not been studied. Do not drive if you feel dizzy or unwell.
- Piproshot 4.5g is a registered product of Ramnova Healthcare Private Limited, Silvassa, India, and is marketed by Ramnova Healthcare.
- Piproshot 4.5g Injection contains piperacillin 4 g and tazobactam 500 mg in each vial.
What is Piproshot 4.5g Injection used for?
What are the side effects of Piproshot 4.5g Injection?
How should I take Piproshot 4.5g Injection?
Who should not take Piproshot 4.5g Injection?
Can I drink alcohol with Piproshot 4.5g Injection?
Is Piproshot 4.5g Injection safe in pregnancy?
Can I drive after taking Piproshot 4.5g Injection?
Who markets Piproshot 4.5g Injection?
What is the composition of Piproshot 4.5g Injection?
More information
Marketed by Ramnova Healthcare Private Limited, Silvassa, India.
For dosage, pack sizes or prescribing information, refer to the current pack insert or contact Ramnova Healthcare. Catalogue information updated 2026-10-01.
- electronic medicines compendium (emc): Piperacillin/tazobactam 4 g/0.5 g powder for solution for infusion: Summary of Product Characteristics (United Kingdom, accessed 2026-10-01)
